Cell line name |
CEM.NKR-CCR5 |
Synonyms |
CEM.NKR CCR5+ |
Accession |
CVCL_X623 |
Resource Identification Initiative |
To cite this cell line use: CEM.NKR-CCR5 (RRID:CVCL_X623) |
Comments |
Population: Caucasian. Characteristics: Resistant to NK cell-mediated cell lysis (from parent cell line). Transfected with: HGNC; 1606; CCR5. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_X622 (CEM.NKR) Children:
|
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
Web pages |
https://www.quora.com/What-are-features-of-the-CEM-NKR-CCR5-cell-line |
Publications | PubMed=10516002; DOI=10.1128/JVI.73.11.8966-8974.1999 Trkola A., Matthews J., Gordon C., Ketas T.J., Moore J.P. A cell line-based neutralization assay for primary human immunodeficiency virus type 1 isolates that use either the CCR5 or the CXCR4 coreceptor. J. Virol. 73:8966-8974(1999) |
Cross-references |
Cell line collections (Providers) |
HIVReagentProgram; ARP-4376
|
Cell line databases/resources |
CLO; CLO_0037252
cancercelllines; CVCL_X623
|
Encyclopedic resources |
Wikidata; Q54809263
|
Entry history |
Entry creation | 05-Sep-2014 |
Last entry update | 05-Oct-2023 |
Version number | 17 |
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