ID   Sup-T1-CCR5
AC   CVCL_X633
SY   SupT1/CCR5; SupT1-CCR5
DR   cancercelllines; CVCL_X633
DR   Wikidata; Q54970881
RX   PubMed=11264379;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 1606; CCR5.
CC   Miscellaneous: STR profile from personal communication of Fernandez M.
CC   Caution: There seem to be at least 6 different cell lines derived from Sup-T1 by transfection of human CCR5: Sup-T1-CCR5 (Cellosaurus=CVCL_X633), SupT1.CCR5 (Cellosaurus=CVCL_WU88), SupT1-R5 (Cellosaurus=CVCL_WU89), Sup-T1 CCR5+ H6 (Cellosaurus=CVCL_A9NU), Sup-T1 CCR5+ L23 (Cellosaurus=CVCL_A9NV) and Sup-T1 CCR5+ M10 (Cellosaurus=CVCL_A9NW).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: T-cell; CL=CL_0000084.
ST   Source(s): Direct_author_submission
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11,12
ST   D13S317: 11,12
ST   D16S539: 9,12,13
ST   D18S51: 13,14
ST   D21S11: 27,28,32,33
ST   D3S1358: 16,17,18,19,20
ST   D5S818: 11
ST   D7S820: 11
ST   D8S1179: 13,14
ST   FGA: 19,20,21
ST   Penta D: 12
ST   Penta E: 14,16
ST   TH01: 9.3
ST   TPOX: 9
ST   vWA: 16,17,18,19
DI   NCIt; C7210; Childhood T lymphoblastic lymphoma
DI   ORDO; Orphanet_171918; T-cell non-Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1714 ! SUP-T1
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 05-10-23; Version: 16
//
RX   PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001;
RA   Means R.E., Matthews T., Hoxie J.A., Malim M.H., Kodama T.,
RA   Desrosiers R.C.;
RT   "Ability of the V3 loop of simian immunodeficiency virus to serve as a
RT   target for antibody-mediated neutralization: correlation of
RT   neutralization sensitivity, growth in macrophages, and decreased
RT   dependence on CD4.";
RL   J. Virol. 75:3903-3915(2001).
//