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Cellosaurus U87-CD4 clone 2 (CVCL_X702)

[Text version]
Cell line name U87-CD4 clone 2
Synonyms U87MG clone 2
Accession CVCL_X702
Resource Identification Initiative To cite this cell line use: U87-CD4 clone 2 (RRID:CVCL_X702)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Transfected with: HGNC; 1678; CD4.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Sequence variations
  • Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2293663; DOI=10.1128/JVI.64.1.215-221.1990
Chesebro B.W., Buller R., Portis J.L., Wehrly K.
Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells.
J. Virol. 64:215-221(1990)

PubMed=8095307; DOI=10.1128/JVI.67.4.2355-2359.1993
Dragic T., Alizon M.
Different requirements for membrane fusion mediated by the envelopes of human immunodeficiency virus types 1 and 2.
J. Virol. 67:2355-2359(1993)

Cross-references
Cell line collections (Providers) HIVReagentProgram; ARP-2187
Cell line databases/resources cancercelllines; CVCL_X702
Encyclopedic resources Wikidata; Q54973747
Entry history
Entry creation05-Sep-2014
Last entry update05-Oct-2023
Version number12