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Cellosaurus HH4 (CVCL_X906)

[Text version]
Cell line name HH4
Accession CVCL_X906
Resource Identification Initiative To cite this cell line use: HH4 (RRID:CVCL_X906)
Comments Population: Caucasian.
Characteristics: Compared to the parent cell line, does not require a feeder layer in order to form colonies in soft agarose.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
Sequence variations
  • Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from parent cell line).
Disease Hereditary spherocytosis (NCIt: C97074)
Hereditary spherocytosis (ORDO: Orphanet_822)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6544 (WIL2)
Children:
CVCL_0561 (TK6)
Sex of cell Male
Age at sampling 5Y
Category Transformed cell line
Publications

PubMed=214074; DOI=10.1016/0006-291X(78)90185-7
Skopek T.R., Liber H.L., Penman B.W., Thilly W.G.
Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay.
Biochem. Biophys. Res. Commun. 84:411-416(1978)

Patent=US4302535
Skopek T.R., Liber H.L., Penman B.W., Thilly W.G., Hoppe H. IV
Assay for mutagenesis in heterozygous diploid human lymphoblasts.
Patent number US4302535, 24-Nov-1981

PubMed=6810168; DOI=10.1016/0027-5107(82)90308-6
Liber H.L., Thilly W.G.
Mutation assay at the thymidine kinase locus in diploid human lymphoblasts.
Mutat. Res. 94:467-485(1982)

Cross-references
Encyclopedic resources Wikidata; Q54887478
Entry history
Entry creation05-Sep-2014
Last entry update29-Jun-2023
Version number11