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Cellosaurus KK-1 [Human leukemia] (CVCL_X908)

Cell line name KK-1 [Human leukemia]
Synonyms KK1
Accession CVCL_X908
Resource Identification Initiative To cite this cell line use: KK-1 [Human leukemia] (RRID:CVCL_X908)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
Disease Adult T-cell leukemia/lymphoma (NCIt: C3184)
Adult T-cell leukemia/lymphoma (ORDO: Orphanet_86875)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_X909 ! KK-5
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line
Publications

PubMed=1861543; DOI=10.1016/0145-2126(91)90031-N
Yamada Y., Nagata Y., Kamihira S., Tagawa M., Ichimaru M., Tomonaga M., Shiku H.
IL-2-dependent ATL cell lines with phenotypes differing from the original leukemia cells.
Leuk. Res. 15:619-625(1991)

PubMed=9172809; DOI=10.3109/10428199609093442
Yamada Y., Ohmoto Y., Hata T., Yamamura M., Murata K., Tsukasaki K., Kohno T., Chen Y.-X., Kamihira S., Tomonaga M.
Features of the cytokines secreted by adult T cell leukemia (ATL) cells.
Leuk. Lymphoma 21:443-447(1996)

PubMed=9596675; DOI=10.1182/blood.V91.11.4265
Yamada Y., Sugawara K., Hata T., Tsuruta K., Moriuchi R., Maeda T., Atogami S., Murata K., Fujimoto K., Kohno T., Tsukasaki K., Tomonaga M., Hirakata Y.-i., Kamihira S.
Interleukin-15 (IL-15) can replace the IL-2 signal in IL-2-dependent adult T-cell leukemia (ATL) cell lines: expression of IL-15 receptor alpha on ATL cells.
Blood 91:4265-4272(1998)

PubMed=10190897; DOI=10.1084/jem.189.7.1063
Maeda T., Yamada Y., Moriuchi R., Sugahara K., Tsuruda K., Joh T., Atogami S., Tsukasaki K., Tomonaga M., Kamihira S.
Fas gene mutation in the progression of adult T cell leukemia.
J. Exp. Med. 189:1063-1071(1999)

PubMed=10570904; DOI=10.1007/s100380050178
Ariyama Y., Mori T., Shinomiya T., Sakabe T., Fukuda Y., Kanamaru A., Yamada Y., Isobe M., Seto M., Nakamura Y., Inazawa J.
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines.
J. Hum. Genet. 44:357-363(1999)

PubMed=15638862; DOI=10.1111/j.1365-2141.2004.05289.x
Hasegawa H., Yamada Y., Harasawa H., Tsuji T., Murata K., Sugahara K., Tsuruda K., Ikeda S., Imaizumi Y., Tomonaga M., Masuda M., Takasu N., Kamihira S.
Sensitivity of adult T-cell leukaemia lymphoma cells to tumour necrosis factor-related apoptosis-inducing ligand.
Br. J. Haematol. 128:253-265(2005)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Kamihira S., Terada C., Sasaki D., Yanagihara K., Tsukasaki K., Hasegawa H., Yamada Y.
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19710698; DOI=10.1038/leu.2009.171
Hasegawa H., Yamada Y., Iha H., Tsukasaki K., Nagai K., Atogami S., Sugahara K., Tsuruda K., Ishizaki A., Kamihira S.
Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.
Leukemia 23:2090-2101(2009)

PubMed=27193821; DOI=10.1111/cas.12971
Hasegawa H., Bissonnette R.P., Gillings M., Sasaki D., Taniguchi H., Kitanosono H., Tsuruda K., Kosai K., Uno N., Morinaga Y., Imaizumi Y., Miyazaki Y., Yanagihara K.
Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3.
Cancer Sci. 107:1124-1133(2016)

CLPUB00592
Patel V.M.
Functional interrogations of phospholipase c gamma 1 (PLCG1) mutations in Sezary syndrome.
Thesis PhD (2019), King's College London, United Kingdom

Cross-references
Cell line databases/resources cancercelllines; CVCL_X908
CGH-DB; 9028-4
Encyclopedic resources Wikidata; Q54899965
Polymorphism and mutation databases IARC_TP53; 26998
Entry history
Entry creation05-Sep-2014
Last entry update05-Oct-2023
Version number13