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Cellosaurus PC9-TGL (CVCL_XA18)

[Text version]

Cell line name PC9-TGL
Accession CVCL_XA18
Resource Identification Initiative To cite this cell line use: PC9-TGL (RRID:CVCL_XA18)
Comments Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Omics: Deep RNAseq analysis.
Omics: Transcriptome analysis.
Caution: In PubMed=19576624, PubMed=28283064 and the associated GEO data sets H2030-TGL is termed PC9 Parental.
Sequence variations EGFR p.Glu746_Ala750del (c.2235_2249del15) (from parent cell line).
Homozygous for TP53 p.Arg248Gln (c.743G>A) (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Children:
CVCL_XA19 (PC9-BrM3)CVCL_XA20 (PC9-LeptoM)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=19576624; DOI=10.1016/j.cell.2009.04.030
Nguyen D.X., Chiang A.C., Zhang X.H.-F., Kim J.Y., Kris M.G., Ladanyi M., Gerald W.L., Massague J.
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Cell 138:51-62(2009)

PubMed=28283064; DOI=10.1016/j.cell.2017.02.025
Boire A., Zou Y., Shieh J., Macalinao D.G., Pentsova E., Massague J.
Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
Cell 168:1101-1113.e13(2017)

Cross-references
Gene expression databases GEO; GSM354009
GEO; GSM354010
GEO; GSM2194116
GEO; GSM2194117
GEO; GSM2194118
Entry history
Entry creation06-Sep-2019
Last entry updated06-Sep-2019
Version number1