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Cellosaurus MDA231-LeptoM (CVCL_XB00)

[Text version]

Cell line name MDA231-LeptoM
Synonyms MDA231 LeptoM; MDA-LeptoM
Accession CVCL_XB00
Resource Identification Initiative To cite this cell line use: MDA231-LeptoM (RRID:CVCL_XB00)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Part of: Brain metastasis cell lines panel.
Characteristics: Brain leptomeningeal space metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracisternal injection, followed by one passage from intracardiac injection and obtained from mice bearing leptomeningeal metastases.
Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
Omics: Deep RNAseq analysis.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VR35 (MDA231-TGL)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Web pages https://apps.cnio.es/app/BrainMetastasis/CellLines
Publications

PubMed=28283064; DOI=10.1016/j.cell.2017.02.025
Boire A., Zou Y., Shieh J., Macalinao D.G., Pentsova E., Massague J.
Complement component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
Cell 168:1101-1113.e13(2017)

Cross-references
Gene expression databases GEO; GSM2194114
GEO; GSM2194115
Other Wikidata; Q95987482
Entry history
Entry creation06-Sep-2019
Last entry update20-May-2021
Version number6