ID   MDA231-LeptoM
AC   CVCL_XB00
SY   MDA231 LeptoM; MDA-LeptoM
DR   GEO; GSM2194114
DR   GEO; GSM2194115
DR   Wikidata; Q95987482
RX   PubMed=28283064;
WW   https://apps.cnio.es/app/BrainMetastasis/CellLines
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Part of: Brain metastasis cell lines panel.
CC   Population: Caucasian.
CC   Characteristics: Brain leptomeningeal space metastatic derivative of parental cell line. Established after 3 passages in nude mice from intracisternal injection, followed by one passage from intracardiac injection and obtained from mice bearing leptomeningeal metastases.
CC   Characteristics: Transfected with HSV1-TK/GFP/Fluc (TGL).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Omics: Deep RNAseq analysis.
CC   Derived from metastatic site: Pleural effusion.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_VR35 ! MDA231-TGL
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 23-09-21; Version: 7
//
RX   PubMed=28283064; DOI=10.1016/j.cell.2017.02.025;
RA   Boire A., Zou Y.-L., Shieh J., Macalinao D.G., Pentsova E.,
RA   Massague J.;
RT   "Complement component 3 adapts the cerebrospinal fluid for
RT   leptomeningeal metastasis.";
RL   Cell 168:1101-1113.e13(2017).
//