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Cellosaurus SKOV3/VP16 (CVCL_XB81)

[Text version]

Cell line name SKOV3/VP16
Accession CVCL_XB81
Resource Identification Initiative To cite this cell line use: SKOV3/VP16 (RRID:CVCL_XB81)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C200905.
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line
Publications

Patent=CN101503675B
Liu S.-L., Wang H., Chen X.-L.
Oophoroma multidrug resistance cell strain established by etoposide induction.
Patent number CN101503675B, 12-Jan-2011

Cross-references
Cell line databases/resources CCRID; 4201PAT-CCTCC00273
Other Wikidata; Q98132685
Entry history
Entry creation06-Sep-2019
Last entry update23-Sep-2021
Version number5