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Cellosaurus A375sci (CVCL_XE59)

[Text version]
Cell line name A375sci
Accession CVCL_XE59
Resource Identification Initiative To cite this cell line use: A375sci (RRID:CVCL_XE59)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C200954.
Population: Caucasian.
Characteristics: Highly metastatic.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

Patent=CN102067828B
Yao M., Wang X.-M., Yan M.-X., Kong H.-W., Liu L., Sa B.-Q., Li J.
Highly metastatic model of human melanoma, cell subline, creation methods, and dynamic detection of metastasis.
Patent number CN102067828B, 10-Jul-2013

Cross-references
Cell line databases/resources cancercelllines; CVCL_XE59
CCRID; 4201PAT-CCTCC00306
Encyclopedic resources Wikidata; Q93311762
Entry history
Entry creation06-Sep-2019
Last entry update05-Oct-2023
Version number10