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Cellosaurus JPM50.6 (CVCL_XF36)

[Text version]

Cell line name JPM50.6
Synonyms JPM 50.6; Jurkat PMA-deficient Mutant clone 50.6
Accession CVCL_XF36
Resource Identification Initiative To cite this cell line use: JPM50.6 (RRID:CVCL_XF36)
Comments Characteristics: CARMA1-deficient mutant.
Characteristics: The eGFP reporter gene is under the control of four tandem copies of the NF-kappaB response element.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (from parent cell line).
Heterozygous for BAX p.Glu41Glyfs*33 (c.121dupG) (ClinVar=VCV000009511) (from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).
Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) (from parent cell line).
Heterozygous for INPP5D c.1097+1065_1097+1112del47 (from parent cell line).
Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (ClinVar=VCV000090903) (from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (ClinVar=VCV000089363) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XF35 (JGFP1)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Publications

PubMed=12154356; DOI=10.1038/ni824
Wang D., You Y., Case S.M., McAllister-Lucas L.M., Wang L., DiStefano P.S., Nunez G., Bertin J., Lin X.
A requirement for CARMA1 in TCR-induced NF-kappa B activation.
Nat. Immunol. 3:830-835(2002)

Cross-references
Other Wikidata; Q94331692
Entry history
Entry creation06-Sep-2019
Last entry update12-Jan-2021
Version number5