ID   UTA21.15
AC   CVCL_XF82
DR   Wikidata; Q98134393
RX   PubMed=9484832;
RX   PubMed=10913154;
CC   Population: Caucasian.
CC   Characteristics: Expresses very little CDKN1A when cultured in the presence of tetracycline, whereas CDKN1A expression is dramatically induced upon removal of tetracycline from the culture medium.
CC   Characteristics: Transfected with an expression plasmid containing CKN1A (p21waf1) under control of a minimal CMV promoter fused to tetracycline operator sequences.
CC   Transfected with: HGNC; 1784; CDKN1A.
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_XF79 ! UTA6
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 29-06-23; Version: 7
//
RX   PubMed=9484832; DOI=10.1038/sj.onc.1201558;
RA   Medema R.H., Klompmaker R., Smits V.A.J., Rijksen G.;
RT   "p21waf1 can block cells at two points in the cell cycle, but does not
RT   interfere with processive DNA-replication or stress-activated
RT   kinases.";
RL   Oncogene 16:431-441(1998).
//
RX   PubMed=10913154; DOI=10.1074/jbc.M005437200;
RA   Smits V.A.J., Klompmaker R., Vallenius T., Rijksen G., Makela T.P.,
RA   Medema R.H.;
RT   "p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA
RT   damage checkpoint.";
RL   J. Biol. Chem. 275:30638-30643(2000).
//