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Cellosaurus UTA21.9 (CVCL_XF83)

[Text version]

Cell line name UTA21.9
Accession CVCL_XF83
Resource Identification Initiative To cite this cell line use: UTA21.9 (RRID:CVCL_XF83)
Comments Characteristics: Expresses very little CDKN1A when cultured in the presence of tetracycline, whereas CDKN1A expression is dramatically induced upon removal of tetracycline from the culture medium.
Characteristics: Transfected with an expression plasmid containing CKN1A (p21waf1) under control of a minimal CMV promoter fused to tetracycline operator sequences.
Transfected with: HGNC; 1784; CDKN1A.
Transfected with: UniProtKB; P04483; E.coli Tn10 tetR.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from sampling site: Bone; tibia.
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_XF79 (UTA6)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line

PubMed=9484832; DOI=10.1038/sj.onc.1201558
Medema R.H., Klompmaker R., Smits V.A.J., Rijksen G.
p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases.
Oncogene 16:431-441(1998)

Entry history
Entry creation06-Sep-2019
Last entry update12-Mar-2020
Version number2