ID   TRMP
AC   CVCL_XG04
DR   Wikidata; Q98133543
RX   PubMed=1314164;
RX   PubMed=1375321;
RX   PubMed=1688246;
RX   PubMed=2550144;
RX   PubMed=3233532;
RX   PubMed=7669722;
RX   PubMed=8069455;
RX   PubMed=8443409;
CC   Characteristics: Does not express PDGFRs (PubMed=2550144).
CC   Doubling time: 24 hours (PubMed=7669722).
CC   Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Breed/subspecies: Beagle.
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Female
CA   Spontaneously immortalized cell line
DT   Created: 06-09-19; Last updated: 29-06-23; Version: 5
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RX   PubMed=1314164; DOI=10.1002/j.1460-2075.1992.tb05182.x;
RA   Kashishian A.S., Kazlauskas A., Cooper J.A.;
RT   "Phosphorylation sites in the PDGF receptor with different
RT   specificities for binding GAP and PI3 kinase in vivo.";
RL   EMBO J. 11:1373-1382(1992).
//
RX   PubMed=1375321; DOI=10.1128/mcb.12.6.2534-2544.1992;
RA   Kazlauskas A., Kashishian A.S., Cooper J.A., Valius M.;
RT   "GTPase-activating protein and phosphatidylinositol 3-kinase bind to
RT   distinct regions of the platelet-derived growth factor receptor beta
RT   subunit.";
RL   Mol. Cell. Biol. 12:2534-2544(1992).
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RX   PubMed=1688246; DOI=10.1097/00008571-199112000-00005;
RA   Turker M.S., Duffin K.Z., Smith A.C., Martin G.M., Martin A.W.,
RA   DiMartino D.L., Kersey D.S.;
RT   "Multidrug resistance phenotype associated with selection of an
RT   aminopterin resistant dog kidney cell line.";
RL   Pharmacogenetics 1:149-160(1991).
//
RX   PubMed=2550144; DOI=10.1016/0092-8674(89)90510-2;
RA   Kazlauskas A., Cooper J.A.;
RT   "Autophosphorylation of the PDGF receptor in the kinase insert region
RT   regulates interactions with cell proteins.";
RL   Cell 58:1121-1133(1989).
//
RX   PubMed=3233532; DOI=10.1007/BF00119247;
RA   Turker M.S., Monnat R.J. Jr., Fukuchi K.-i., Johnston P.A.,
RA   Ogburn C.E., Weller R.E., Park J.F., Martin G.M.;
RT   "A novel class of unstable 6-thioguanine-resistant cells from dog and
RT   human kidneys.";
RL   Cell Biol. Toxicol. 4:211-223(1988).
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RX   PubMed=7669722;
RA   Chen S.-C., Pelletier D.B., Ao P., Boynton A.L.;
RT   "Connexin43 reverses the phenotype of transformed cells and alters
RT   their expression of cyclin/cyclin-dependent kinases.";
RL   Cell Growth Differ. 6:681-690(1995).
//
RX   PubMed=8069455; DOI=10.1007/BF02631450;
RA   Fukuchi K.-i., Hearn M.G., Deeb S.S., Smith A.C., Ngoc Thao D.,
RA   Miyazaki J.-i., Bothwell M., Martin G.M.;
RT   "Activity assays of nine heterogeneous promoters in neural and other
RT   cultured cells.";
RL   In Vitro Cell. Dev. Biol. Anim. 30:300-305(1994).
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RX   PubMed=8443409; DOI=10.1091/mbc.4.1.49;
RA   Kashishian A.S., Cooper J.A.;
RT   "Phosphorylation sites at the C-terminus of the platelet-derived
RT   growth factor receptor bind phospholipase C gamma 1.";
RL   Mol. Biol. Cell 4:49-57(1993).
//