ID   NCCIT_CDDP
AC   CVCL_XI44
DR   Wikidata; Q95992667
RX   PubMed=31500094;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Mutation; HGNC; 6844; MAP2K4; Simple; p.Lys309Asn (c.927G>C); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Arg173Pro (c.518G>C); ClinVar=VCV000185195; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val272Cysfs*73 (c.814delG); Zygosity=Homozygous (from parent cell line).
DI   NCIt; C6341; Testicular embryonal carcinoma
DI   ORDO; Orphanet_289362; Non-central nervous system-localized embryonal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_1451 ! NCC-IT
SX   Male
AG   24Y
CA   Cancer cell line
DT   Created: 19-12-19; Last updated: 20-05-21; Version: 6
//
RX   PubMed=31500094; DOI=10.3390/cancers11091316;
RA   Bakardjieva-Mihaylova V., Skvarova Kramarzova K., Slamova M.,
RA   Svaton M., Rejlova K., Zaliova M., Dobiasova A., Fiser K., Stuchly J.,
RA   Grega M., Rosova B., Zachoval R., Klezl P., Eis V., Kindlova E.,
RA   Buchler T., Trka J., Boublikova L.;
RT   "Molecular basis of cisplatin resistance in testicular germ cell
RT   tumors.";
RL   Cancers (Basel) 11:1316.1-1316.18(2019).
//