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Cellosaurus THP-1 TLR9 mCherry (CVCL_XI47)

[Text version]
Cell line name THP-1 TLR9 mCherry
Accession CVCL_XI47
Resource Identification Initiative To cite this cell line use: THP-1 TLR9 mCherry (RRID:CVCL_XI47)
Comments Population: Japanese.
Characteristics: Transfected with a Tet-on system so as to induce the expression of a TLR9-mCherry fusion protein with the addition of doxycycline to the culture medium.
Transfected with: HGNC; 15633; TLR9.
Transfected with: UniProtKB; X5DSL3; Anaplasma marginale mCherry fluorescent protein.
Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

CLPUB00539
Cemalovic E.
TLR9 trafficking and signaling.
Thesis MSc (2019), Norwegian University of Science and Technology, Norway

CLPUB00540
Wang C.
Characterization of a model cell line to study Toll-like receptor 9 signaling and trafficking.
Thesis MSc (2019), Norwegian University of Science and Technology, Norway

Cross-references
Cell line databases/resources cancercelllines; CVCL_XI47
Encyclopedic resources Wikidata; Q98133245
Entry history
Entry creation19-Dec-2019
Last entry update05-Oct-2023
Version number9