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Cellosaurus HepG2-CYP2B6-hCAR (CVCL_XI69)

[Text version]

Cell line name HepG2-CYP2B6-hCAR
Accession CVCL_XI69
Resource Identification Initiative To cite this cell line use: HepG2-CYP2B6-hCAR (RRID:CVCL_XI69)
Comments Population: Caucasian.
Transfected with: HGNC; 2615; CYP2B6.
Transfected with: HGNC; 7969; NR1I3.
Transfected with: UniProtKB; P08659; Firefly luciferase (with optimized codon usage for mammalian expression).
Transfected with: UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from sampling site: Liver.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line

PubMed=25993555; DOI=10.1038/srep10405
Lynch C., Zhao J.-H., Huang R.-L., Xiao J.-W., Li L.-H., Heyward S., Xia M.-H., Wang H.-B.
Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.
Sci. Rep. 5:10405-10405(2015)

PubMed=27518621; DOI=10.1007/978-1-4939-6346-1_4
Lynch C., Zhao J.-H., Wang H.-B., Xia M.-H.
Quantitative high-throughput luciferase screening in identifying CAR modulators.
Methods Mol. Biol. 1473:33-42(2016)

Other Wikidata; Q94103346
Entry history
Entry creation19-Dec-2019
Last entry update20-May-2021
Version number6