ID   HepG2-CYP2B6-hCAR
AC   CVCL_XI69
DR   Wikidata; Q94103346
RX   PubMed=25993555;
RX   PubMed=27518621;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: HGNC; 2615; CYP2B6.
CC   Transfected with: HGNC; 7969; NR1I3.
CC   Transfected with: UniProtKB; P08659; Firefly luciferase (with optimized codon usage for mammalian expression).
CC   Transfected with: UniProtKB; P0C2P0; Aspergillus terreus blasticidin-S deaminase (Bsd).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from sampling site: Liver.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 19-12-19; Last updated: 20-05-21; Version: 6
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RX   PubMed=25993555; DOI=10.1038/srep10405;
RA   Lynch C., Zhao J.-H., Huang R.-L., Xiao J.-W., Li L.-H., Heyward S.,
RA   Xia M.-H., Wang H.-B.;
RT   "Quantitative high-throughput identification of drugs as modulators of
RT   human constitutive androstane receptor.";
RL   Sci. Rep. 5:10405-10405(2015).
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RX   PubMed=27518621; DOI=10.1007/978-1-4939-6346-1_4;
RA   Lynch C., Zhao J.-H., Wang H.-B., Xia M.-H.;
RT   "Quantitative high-throughput luciferase screening in identifying CAR
RT   modulators.";
RL   Methods Mol. Biol. 1473:33-42(2016).
//