ID   HaCaT40degree
AC   CVCL_XK18
DR   Wikidata; Q93937740
RX   PubMed=10523843;
RX   PubMed=11583982;
CC   Population: Caucasian.
CC   Characteristics: Adapted to grow at 40 Celsius.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 5173; HRAS.
CC   Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0038 ! HaCaT
SX   Male
AG   62Y
CA   Spontaneously immortalized cell line
DT   Created: 19-12-19; Last updated: 29-06-23; Version: 8
//
RX   PubMed=10523843; DOI=10.1038/sj.onc.1202934;
RA   Boukamp P., Popp S., Bleuel K., Tomakidi E., Burkle A., Fusenig N.E.;
RT   "Tumorigenic conversion of immortal human skin keratinocytes (HaCaT)
RT   by elevated temperature.";
RL   Oncogene 18:5638-5645(1999).
//
RX   PubMed=11583982; DOI=10.1016/S0002-9440(10)62541-2;
RA   Mueller M.M., Peter W., Mappes M., Huelsen A., Steinbauer H.,
RA   Boukamp P., Vaccariello M.A., Garlick J.A., Fusenig N.E.;
RT   "Tumor progression of skin carcinoma cells in vivo promoted by clonal
RT   selection, mutagenesis, and autocrine growth regulation by granulocyte
RT   colony-stimulating factor and granulocyte-macrophage
RT   colony-stimulating factor.";
RL   Am. J. Pathol. 159:1567-1579(2001).
//