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Cellosaurus AsPC1-R (CVCL_XX79)

[Text version]

Cell line name AsPC1-R
Accession CVCL_XX79
Resource Identification Initiative To cite this cell line use: AsPC1-R (RRID:CVCL_XX79)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Omics: Transcriptome analysis.
Sequence variations Gene deletion; HGNC; 6844; MAP2K4; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1787; CDKN2A; Simple; p.Leu78Hisfs*41 (c.233_234delTC) (p.His93Profs*67, c.276_277delTC); ClinVar=VCV000977782; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 6770; SMAD4; Simple; p.Arg100Thr (c.299G>C); Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Cys135Alafs*35 (c.403delT); Zygosity=Heterozygous (from parent cell line).
Disease Pancreatic ductal adenocarcinoma (NCIt: C9120)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0152 (AsPC-1)
Sex of cell Female
Age at sampling 62Y
Category Cancer cell line
Publications

PubMed=27910856; DOI=10.1038/cgt.2016.71
Mezencev R., Matyunina L.V., Wagner G.T., McDonald J.F.
Acquired resistance of pancreatic cancer cells to cisplatin is multifactorial with cell context-dependent involvement of resistance genes.
Cancer Gene Ther. 23:446-453(2016)

Cross-references
Encyclopedic resources Wikidata; Q93326176
Gene expression databases GEO; GSM1906988
GEO; GSM1906989
GEO; GSM1906990
Entry history
Entry creation19-Dec-2019
Last entry update20-May-2021
Version number5