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Cellosaurus U937/clone21 (CVCL_Y170)

[Text version]

Cell line name U937/clone21
Accession CVCL_Y170
Resource Identification Initiative To cite this cell line use: U937/clone21 (RRID:CVCL_Y170)
Comments Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Derived from sampling site: Pleural effusion.
Sequence variations PICALM-MLLT10 (CALM-AF10) gene fusion (from parent cell line).
Hemizygous for PTEN p.Gly129fs*51 (c.387_388insCGCC) (from parent cell line).
Homozygous for TP53 c.559+1G>A (p.Val173Trpfs*59); splice donor mutation (from parent cell line).
Disease Adult acute monocytic leukemia (NCIt: C8263)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0007 (U-937)
Sex of cell Male
Age at sampling 37Y
Category Cancer cell line
Publications

PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J.
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004)

Cross-references
Cell line databases/resources CGH-DB; 9116-4
Other Wikidata; Q54973779
Entry history
Entry creation07-Nov-2014
Last entry update02-Jul-2020
Version number7