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Cellosaurus SKOV3/VP (CVCL_Y280)

Cell line name SKOV3/VP
Accession CVCL_Y280
Resource Identification Initiative To cite this cell line use: SKOV3/VP (RRID:CVCL_Y280)
Comments Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Sequence variations Heterozygous for APC p.Thr1556fs*9 (c.4666delA) (from parent cell line).
Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (from parent cell line).
Homozygous for TP53 p.Ser90fs*33 (c.267delC) (from parent cell line).
Disease Ovarian serous cystadenocarcinoma (NCIt: C7978)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0532 (SK-OV-3)
Sex of cell Female
Age at sampling 64Y
Category Cancer cell line

PubMed=7911742; DOI=10.1007/BF00685075
Kubota N., Nishio K., Takeda Y., Ohmori T., Funayama Y., Ogasawara H., Ohira T., Kunikane H., Terashima Y., Saijo N.
Characterization of an etoposide-resistant human ovarian cancer cell line.
Cancer Chemother. Pharmacol. 34:183-190(1994)

PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Yasui K., Mihara S., Zhao C., Okamoto H., Saito-Ohara F., Tomida A., Funato T., Yokomizo A., Naito S., Imoto I., Tsuruo T., Inazawa J.
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004)

Cell line databases/resources CGH-DB; 9125-4
Other Wikidata; Q54954774