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Cellosaurus L1210/DDP5 (CVCL_Y422)

[Text version]

Cell line name L1210/DDP5
Synonyms L1210(DDP5); L1210 (DDP5); L1210DDP5
Accession CVCL_Y422
Resource Identification Initiative To cite this cell line use: L1210/DDP5 (RRID:CVCL_Y422)
Comments Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
Derived from sampling site: Ascites.
Disease Mouse leukemia (NCIt: C21604)
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: DBA/2.
Hierarchy Parent: CVCL_0382 (L1210)
Sex of cell Female
Age at sampling 8M
Category Cancer cell line
Publications

PubMed=6541096
Eastman A., Illenye S.
Murine leukemia L1210 cell lines with different patterns of resistance to platinum coordination complexes.
Cancer Treat. Rep. 68:1189-1190(1984)

PubMed=3828995
Richon V.M., Schulte N., Eastman A.
Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II) in murine leukemia L1210 cells.
Cancer Res. 47:2056-2061(1987)

PubMed=3167012; DOI=10.1021/bi00413a022
Eastman A., Schulte N.
Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II).
Biochemistry 27:4730-4734(1988)

PubMed=3335002
Kraker A.J., Moore C.W.
Accumulation of cis-diamminedichloroplatinum(II) and platinum analogues by platinum-resistant murine leukemia cells in vitro.
Cancer Res. 48:9-13(1988)

PubMed=1986276; DOI=10.1016/0921-8777(91)90044-P
Jennerwein M.M., Eastman A., Khokhar A.R.
The role of DNA repair in resistance of L1210 cells to isomeric 1,2-diaminocyclohexaneplatinum complexes and ultraviolet irradiation.
Mutat. Res. 254:89-96(1991)

PubMed=10200488; DOI=10.1038/sj.cdd.4400357
Segal-Bendirdjian E., Mannone L., Jacquemin-Sablon A.
Alteration in p53 pathway and defect in apoptosis contribute independently to cisplatin-resistance.
Cell Death Differ. 5:390-400(1998)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307477
ChEMBL-Targets; CHEMBL613512
Other Wikidata; Q54900962
Entry history
Entry creation07-Nov-2014
Last entry update02-Jul-2020
Version number9