ID   L1210/DDP5
AC   CVCL_Y422
SY   L1210(DDP5); L1210 (DDP5); L1210DDP5
DR   ChEMBL-Cells; CHEMBL3307477
DR   ChEMBL-Targets; CHEMBL613512
DR   Wikidata; Q54900962
RX   PubMed=1986276;
RX   PubMed=3167012;
RX   PubMed=3335002;
RX   PubMed=3828995;
RX   PubMed=6541096;
RX   PubMed=10200488;
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Transformant: ChEBI; CHEBI:34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
CC   Derived from sampling site: Ascites.
CC   Breed/subspecies: DBA/2.
DI   NCIt; C21604; Mouse leukemia
OX   NCBI_TaxID=10090; ! Mus musculus
HI   CVCL_0382 ! L1210
SX   Female
AG   8M
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 02-07-20; Version: 9
RX   PubMed=1986276; DOI=10.1016/0921-8777(91)90044-P;
RA   Jennerwein M.M., Eastman A., Khokhar A.R.;
RT   "The role of DNA repair in resistance of L1210 cells to isomeric
RT   1,2-diaminocyclohexaneplatinum complexes and ultraviolet
RT   irradiation.";
RL   Mutat. Res. 254:89-96(1991).
RX   PubMed=3167012; DOI=10.1021/bi00413a022;
RA   Eastman A., Schulte N.;
RT   "Enhanced DNA repair as a mechanism of resistance to
RT   cis-diamminedichloroplatinum(II).";
RL   Biochemistry 27:4730-4734(1988).
RX   PubMed=3335002;
RA   Kraker A.J., Moore C.W.;
RT   "Accumulation of cis-diamminedichloroplatinum(II) and platinum
RT   analogues by platinum-resistant murine leukemia cells in vitro.";
RL   Cancer Res. 48:9-13(1988).
RX   PubMed=3828995;
RA   Richon V.M., Schulte N., Eastman A.;
RT   "Multiple mechanisms of resistance to cis-diamminedichloroplatinum(II)
RT   in murine leukemia L1210 cells.";
RL   Cancer Res. 47:2056-2061(1987).
RX   PubMed=6541096;
RA   Eastman A., Illenye S.;
RT   "Murine leukemia L1210 cell lines with different patterns of
RT   resistance to platinum coordination complexes.";
RL   Cancer Treat. Rep. 68:1189-1190(1984).
RX   PubMed=10200488; DOI=10.1038/sj.cdd.4400357;
RA   Segal-Bendirdjian E., Mannone L., Jacquemin-Sablon A.;
RT   "Alteration in p53 pathway and defect in apoptosis contribute
RT   independently to cisplatin-resistance.";
RL   Cell Death Differ. 5:390-400(1998).