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Cellosaurus A375S1 (CVCL_Y439)

[Text version]
Cell line name A375S1
Accession CVCL_Y439
Resource Identification Initiative To cite this cell line use: A375S1 (RRID:CVCL_Y439)
Comments Population: Caucasian.
Miscellaneous: Not sure what is the relationship between A375.S2 and A375S1.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=3261584; DOI=10.1016/0006-291X(88)90266-5
Nakai S., Mizuno K., Kaneta M., Hirai Y.
A simple, sensitive bioassay for the detection of interleukin-1 using human melanoma A375 cell line.
Biochem. Biophys. Res. Commun. 154:1189-1196(1988)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Y439
Encyclopedic resources Wikidata; Q54606878
Entry history
Entry creation07-Nov-2014
Last entry update05-Oct-2023
Version number15