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Cellosaurus HepG3 (CVCL_Y479)

[Text version]

Cell line name HepG3
Accession CVCL_Y479
Resource Identification Initiative To cite this cell line use: HepG3 (RRID:CVCL_Y479)
Comments Miscellaneous: It is not clear if there is a single HepG3 cell line or many differents ones. The one described in PubMed=22912842 is is said to be a Hep-G2 'derived stable cell line containing an integrated wild-type DHBV head-to-tail unit-length genomic DNA dimer', but there seems to be old papers (like PubMed=1828229) using this cell line as if it was obtained from ATCC.
Sequence variations NRAS p.Gln61Leu (c.182A>T) (ClinVar=VCV000375874) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Web pages http://www.protocol-online.org/forums/topic/27211-hepg3-cell-line-origin/

PubMed=22912842; DOI=10.1371/journal.pone.0043270
Guo H., Xu C., Zhou T., Block T.M., Guo J.-T.
Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation.
PLoS ONE 7:E43270-E43270(2012)

Ontologies EFO; EFO_0005382
Other Wikidata; Q54882867
Entry history
Entry creation07-Nov-2014
Last entry update02-Jul-2020
Version number9