ID   HepG3
AC   CVCL_Y479
DR   EFO; EFO_0005382
DR   cancercelllines; CVCL_Y479
DR   Wikidata; Q54882867
RX   PubMed=22912842;
WW   http://www.protocol-online.org/forums/topic/27211-hepg3-cell-line-origin/
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Miscellaneous: It is not clear if there is a single HepG3 cell line or many differents ones. The one described in PubMed=22912842 is is said to be a Hep-G2 'derived stable cell line containing an integrated wild-type DHBV head-to-tail unit-length genomic DNA dimer', but there seem to be old papers (like PubMed 1828229) using this cell line as if it was obtained from ATCC.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 05-10-23; Version: 16
//
RX   PubMed=22912842; DOI=10.1371/journal.pone.0043270;
RA   Guo H.-T., Xu C.-X., Zhou T.-L., Block T.M., Guo J.-T.;
RT   "Characterization of the host factors required for hepadnavirus
RT   covalently closed circular (ccc) DNA formation.";
RL   PLoS ONE 7:E43270-E43270(2012).
//