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Cellosaurus MCF-7R (CVCL_Y493)

[Text version]
Cell line name MCF-7R
Synonyms MCF7R
Accession CVCL_Y493
Resource Identification Initiative To cite this cell line use: MCF-7R (RRID:CVCL_Y493)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=17671737; DOI=10.3892/ijmm.20.3.329
Poma P., Notarbartolo M., Labbozzetta M., Maurici A., Carina V., Alaimo A., Rizzi M., Simoni D., D'Alessandro N.
The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis.
Int. J. Mol. Med. 20:329-335(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Y493
Chemistry resources ChEMBL-Cells; CHEMBL3307593
ChEMBL-Targets; CHEMBL614327
PubChem_Cell_line; CVCL_Y493
Encyclopedic resources Wikidata; Q54904409
Entry history
Entry creation07-Nov-2014
Last entry update05-Oct-2023
Version number17