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Cellosaurus MCF-7R (CVCL_Y493)

[Text version]

Cell line name MCF-7R
Synonyms MCF7R
Accession CVCL_Y493
Resource Identification Initiative To cite this cell line use: MCF-7R (RRID:CVCL_Y493)
Comments Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=17671737; DOI=10.3892/ijmm.20.3.329
Poma P., Notarbartolo M., Labbozzetta M., Maurici A., Carina V., Alaimo A., Rizzi M., Simoni D., D'Alessandro N.
The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis.
Int. J. Mol. Med. 20:329-335(2007)

Chemistry resources ChEMBL-Cells; CHEMBL3307593
ChEMBL-Targets; CHEMBL614327
Other Wikidata; Q54904409
Entry history
Entry creation07-Nov-2014
Last entry update02-Jul-2020
Version number10