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Cellosaurus A549/Asc-1 (CVCL_YA87)

[Text version]
Cell line name A549/Asc-1
Synonyms A549/ASC-1
Accession CVCL_YA87
Resource Identification Initiative To cite this cell line use: A549/Asc-1 (RRID:CVCL_YA87)
Comments Population: Caucasian.
Characteristics: Established following following in vivo propagation of parent cell line as an ascites tumor (PubMed=3129183).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=3129183
Hubbard W.C., Alley M.C., McLemore T.L., Boyd M.R.
Evidence for thromboxane biosynthesis in established cell lines derived from human lung adenocarcinomas.
Cancer Res. 48:2674-2677(1988)

PubMed=3335022
Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., Boyd M.R.
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YA87
Encyclopedic resources Wikidata; Q93312009
Gene expression databases GEO; GSM1177927
GEO; GSM1177928
Entry history
Entry creation19-Dec-2019
Last entry update05-Oct-2023
Version number7