Cell line name |
Jurkat pNFAT-EGFP |
Accession |
CVCL_YB71 |
Resource Identification Initiative |
To cite this cell line use: Jurkat pNFAT-EGFP (RRID:CVCL_YB71) |
Comments |
Population: Caucasian. Characteristics: Expression of the eGFP reporter gene is under control of the NFAT response element. Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP). Transfected with: UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0065 (Jurkat) |
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
Publications | PubMed=22820255; DOI=10.1038/nature11259 Wei P., Wong W.W., Park J.S., Corcoran E.E., Peisajovich S.G., Onuffer J.J., Weiss A., Lim W.A. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature 488:384-388(2012) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_YB71
|
Encyclopedic resources |
Wikidata; Q94332900
|
Entry history |
Entry creation | 19-Dec-2019 |
Last entry update | 05-Oct-2023 |
Version number | 10 |
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