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Cellosaurus Hs578T-delta-hTfR1 (CVCL_YL24)

[Text version]

Cell line name Hs578T-delta-hTfR1
Synonyms Hs578TdeltahTfR1
Accession CVCL_YL24
Resource Identification Initiative To cite this cell line use: Hs578T-delta-hTfR1 (RRID:CVCL_YL24)
Comments Knockout cell: Method=CRISPR/Cas9 (3 of 3 alleles); HGNC; 11763; TFRC.
Derived from sampling site: Breast.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0332 (Hs 578T)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line

PubMed=25980759; DOI=10.1186/s12977-015-0168-2
Konstantoulas C.J., Lamp B., Rumenapf T.H., Indik S.
Single amino acid substitution (G42E) in the receptor binding domain of mouse mammary tumour virus envelope protein facilitates infection of non-murine cells in a transferrin receptor 1-independent manner.
Retrovirology 12:43.1-43.19(2015)

Encyclopedic resources Wikidata; Q94301899
Entry history
Entry creation12-Mar-2020
Last entry update20-May-2021
Version number5