ID   Hs578T-delta-hTfR1
AC   CVCL_YL24
SY   Hs578TdeltahTfR1
DR   cancercelllines; CVCL_YL24
DR   Wikidata; Q94301899
RX   PubMed=25980759;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 11763; TFRC (Note=3 of 3 alleles).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Breast; UBERON=UBERON_0000310.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0332 ! Hs 578T
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 12-03-20; Last updated: 30-01-24; Version: 9
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RX   PubMed=25980759; DOI=10.1186/s12977-015-0168-2;
RA   Konstantoulas C.J., Lamp B., Rumenapf T.H., Indik S.;
RT   "Single amino acid substitution (G42E) in the receptor binding domain
RT   of mouse mammary tumour virus envelope protein facilitates infection
RT   of non-murine cells in a transferrin receptor 1-independent manner.";
RL   Retrovirology 12:43.1-43.19(2015).
//