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Cellosaurus Hep-G2/C3A-hOTC (CVCL_YN90)

[Text version]
Cell line name Hep-G2/C3A-hOTC
Synonyms C3_O
Accession CVCL_YN90
Resource Identification Initiative To cite this cell line use: Hep-G2/C3A-hOTC (RRID:CVCL_YN90)
Comments Population: Caucasian.
Transfected with: HGNC; 8512; OTC.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1098 (Hep-G2/C3A)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

DOI=10.1016/j.bbe.2019.12.006
Pluta K.D., Samluk A., Wencel A., Zakrzewska K.E., Gora M., Burzynska B., Ciezkowska M., Motyl J., Pijanowska D.G.
Genetically modified C3A cells with restored urea cycle for improved bioartificial liver.
Biocybern. Biomed. Eng. 40:378-387(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YN90
Encyclopedic resources Wikidata; Q94102467
Entry history
Entry creation12-Mar-2020
Last entry update05-Oct-2023
Version number8