| Cell line name |
HL-60R |
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| Accession |
CVCL_YT56 |
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| Resource Identification Initiative |
To cite this cell line use: HL-60R (RRID:CVCL_YT56) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:15367; All-trans-retinoic acid (ATRA; Tretinoin).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
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| Sequence variations |
- Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9864; RARA; Simple; p.Gln411Ter (c.1231C>T); Zygosity=Heterozygous; Note=Responsible for retinoic acid resistance (PubMed=1327285).
|
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| Disease |
Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0002 (HL-60) |
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| Sex of cell |
Female |
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| Age at sampling |
36Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=1970118; DOI=10.1128/mcb.10.5.2154-2163.1990
Collins S.J., Robertson K.A., Mueller L.
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).
Mol. Cell. Biol. 10:2154-2163(1990) PubMed=1327285; DOI=10.1182/blood.V80.8.1885.1885
Robertson K.A., Emami B., Collins S.J.
Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity.
Blood 80:1885-1889(1992) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_YT56
|
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| Encyclopedic resources |
Wikidata; Q94211690
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| Entry history |
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| Entry creation | 12-Mar-2020 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 9 |
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