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Cellosaurus ssHUDEP2 (CVCL_YT59)

[Text version]

Cell line name ssHUDEP2
Accession CVCL_YT59
Resource Identification Initiative To cite this cell line use: ssHUDEP2 (RRID:CVCL_YT59)
Comments Population: Japanese.
Derived from sampling site: Umbilical cord blood.
Sequence variations Mutation; HGNC; 4827; HBB; Simple_edited; p.Glu7Val (c.20A>T) (E6V); ClinVar=VCV000015333; Zygosity=Homozygous; Note=By CRISPR/Cas9 (DOI=10.1182/blood-2019-127330).
Disease Sickle cell disease (NCIt: C34383)
Sickle cell anemia (ORDO: Orphanet_232)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_VI06 (HUDEP-2)
Sex of cell Sex unspecified
Age at sampling <1D
Category Transformed cell line
Publications

DOI=10.1182/blood-2019-127330
Gupta D., Sturtevant S., Vieira B., Nakamura Y., Krishnamoorthy S., Demers M.
Characterization of a genetically engineered HUDEP2 cell line harboring a sickle cell disease mutation as a potential research tool for preclinical sickle cell disease drug discovery.
Blood 134 Suppl. 1:3559a-3559a(2019)

Cross-references
Encyclopedic resources Wikidata; Q98132831
Entry history
Entry creation12-Mar-2020
Last entry update20-May-2021
Version number5