| Cell line name |
Huh7.5.1-8 |
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| Accession |
CVCL_YU20 |
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| Resource Identification Initiative |
To cite this cell line use: Huh7.5.1-8 (RRID:CVCL_YU20) |
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| Comments |
Population: Japanese.
Virology: Highly susceptible to infection by hepatitis C virus (HCV).
Omics: Genome sequenced.
Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
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| Sequence variations |
- Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (PubMed=33193621).
- Mutation; HGNC; 19102; RIGI; Simple; p.Thr55Ile (c.164C>T); Zygosity=Heterozygous (PubMed=33193621).
- Mutation; HGNC; 11255; SPP1; Simple; p.Lys241Thr (c.722A>C); Zygosity=Heterozygous; Note=Newly acquired mutation (PubMed=33193621).
- Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
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| Disease |
Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_E049 (Huh-7.5.1) |
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| Sex of cell |
Male |
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| Age at sampling |
57Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=25420655; DOI=10.7883/yoken.JJID.2014.231
Shirasago Y., Sekizuka T., Saito K., Suzuki T., Wakita T., Hanada K., Kuroda M., Abe R., Fukasawa M.
Isolation and characterization of an Huh.7.5.1-derived cell clone highly permissive to hepatitis C virus.
Jpn. J. Infect. Dis. 68:81-88(2015) PubMed=33193621; DOI=10.3389/fgene.2020.546106
Kawamoto M., Yamaji T., Saito K., Shirasago Y., Satomura K., Endo T., Fukasawa M., Hanada K., Osada N.
Identification of characteristic genomic markers in human hepatoma Huh7 and Huh7.5.1-8 cell lines.
Front. Genet. 11:546106.1-546106.10(2020) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_YU20
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| Encyclopedic resources |
Wikidata; Q94308759
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| Entry history |
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| Entry creation | 12-Mar-2020 |
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| Last entry update | 30-Jan-2024 |
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| Version number | 10 |
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