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Cellosaurus MCF7-LTED (CVCL_YX84)

[Text version]

Cell line name MCF7-LTED
Synonyms MCF7 LTED; LTED-I; MCF7-Long Term Estrogen-Deprived
Accession CVCL_YX84
Resource Identification Initiative To cite this cell line use: MCF7-LTED (RRID:CVCL_YX84)
Comments Characteristics: Derived from parental cell line by long-term culture in the presence of RPMI-1640 medium containing 10% dextran charcoal stripped serum (DCC).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=12775708; DOI=10.1074/jbc.M305226200
Martin L.-A., Farmer I., Johnston S.R.D., Ali S., Marshall C., Dowsett M.
Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.
J. Biol. Chem. 278:30458-30468(2003)

PubMed=26116361; DOI=10.1158/1535-7163.MCT-15-0143
Ribas R., Pancholi S., Guest S.K., Marangoni E., Gao Q., Thuleau A., Simigdala N., Polanska U.M., Campbell H., Rani A., Liccardi G., Johnston S.R.D., Davies B.R., Dowsett M., Martin L.-A.
AKT antagonist AZD5363 influences estrogen receptor function in endocrine-resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo.
Mol. Cancer Ther. 14:2035-2048(2015)

Cross-references
Other Wikidata; Q95986792
Entry history
Entry creation12-Mar-2020
Last entry update02-Jul-2020
Version number2