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Cellosaurus ISE6 (CVCL_Z170)

[Text version]

Cell line name ISE6
Accession CVCL_Z170
Resource Identification Initiative To cite this cell line use: ISE6 (RRID:CVCL_Z170)
Comments Group: Tick cell line.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: Metabolome analysis.
Species of origin Ixodes scapularis (Black-legged tick) (Deer tick) (NCBI Taxonomy: 6945)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Spontaneously immortalized cell line
Web pages https://www.liverpool.ac.uk/infection-and-global-health/research/tick-cell-biobank/tick-cell-lines/
https://www.dsmz.de/fileadmin/Bereiche/Microbiology/Dateien/Kultivierungshinweise/TickCellCultureMethods-4.pdf
https://www.vectorbase.org/vbsearch/details/VBRNAseq_group_1255
Publications

PubMed=8812616; DOI=10.1006/jipa.1996.0050
Kurtti T.J., Munderloh U.G., Andreadis T.G., Magnarelli L.A., Mather T.N.
Tick cell culture isolation of an intracellular prokaryote from the tick Ixodes scapularis.
J. Invertebr. Pathol. 67:318-321(1996)

Patent=US5869335
Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A.
Propagating bovine parasite by incubation of undifferentiated cells under low oxygen increased carbon dioxide, with organic buffers efficient, large scale production; diagnosis/vaccine for rocky mountains spotted fever.
Patent number US5869335, 09-Feb-1999

PubMed=16922866; DOI=10.1111/j.1462-5822.2006.00727.x
Singu V., Peddireddi L., Sirigireddy K.R., Cheng C.-M., Munderloh U.G., Ganta R.R.
Unique macrophage and tick cell-specific protein expression from the p28/p30-outer membrane protein multigene locus in Ehrlichia chaffeensis and Ehrlichia canis.
Cell. Microbiol. 8:1475-1487(2006)

PubMed=17662657; DOI=10.1016/j.pt.2007.07.009
Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F.
Tick cell lines: tools for tick and tick-borne disease research.
Trends Parasitol. 23:450-457(2007)

PubMed=19242658; DOI=10.1007/s10493-009-9255-1
Billeter S.A., Diniz P.P.V.P., Battisti J.M., Munderloh U.G., Breitschwerdt E.B., Levy M.G.
Infection and replication of Bartonella species within a tick cell line.
Exp. Appl. Acarol. 49:193-208(2009)

PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002
Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K., Kohl A., Bell-Sakyi L.
Detection and identification of putative bacterial endosymbionts and endogenous viruses in tick cell lines.
Ticks Tick Borne Dis. 3:137-146(2012)

PubMed=25894426; DOI=10.1007/s10493-015-9908-1
Oliver J.D., Chavez A.S.O., Felsheim R.F., Kurtti T.J., Munderloh U.G.
An Ixodes scapularis cell line with a predominantly neuron-like phenotype.
Exp. Appl. Acarol. 66:427-442(2015)

PubMed=26424601; DOI=10.1074/mcp.M115.051938
Villar M., Ayllon N., Alberdi P., Moreno A., Moreno M., Tobes R., Mateos-Hernandez L., Weisheit S., Bell-Sakyi L., de la Fuente J.
Integrated metabolomics, transcriptomics and proteomics identifies metabolic pathways affected by Anaplasma phagocytophilum infection in tick cells.
Mol. Cell. Proteomics 14:3154-3172(2015)

PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015
Bell-Sakyi L., Darby A., Baylis M., Makepeace B.L.
The Tick Cell Biobank: a global resource for in vitro research on ticks, other arthropods and the pathogens they transmit.
Ticks Tick Borne Dis. 9:1364-1371(2018)

PubMed=32158404; DOI=10.3389/fphys.2020.00152
Al-Rofaai A., Bell-Sakyi L.
Tick cell lines in research on tick control.
Front. Physiol. 11:152-152(2020)

Cross-references
Cell line collections ATCC; CRL-11974
TCB; 3051
Other Wikidata; Q54898276
Proteomic databases PRIDE; PXD002181
Entry history
Entry creation10-Apr-2015
Last entry update02-Jul-2020
Version number8