AC   CVCL_Z170
DR   ATCC; CRL-11974
DR   BEI_Resources; NR-12234
DR   PRIDE; PXD002181
DR   TCB; 3051
DR   Wikidata; Q54898276
RX   Patent=US5869335;
RX   PubMed=8812616;
RX   PubMed=16922866;
RX   PubMed=17662657;
RX   PubMed=19242658;
RX   PubMed=22743047;
RX   PubMed=25894426;
RX   PubMed=26424601;
RX   PubMed=29886187;
RX   PubMed=32158404;
RX   PubMed=33389257;
CC   Group: Patented cell line.
CC   Group: Tick cell line.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11974.
CC   Characteristics: Not susceptible to SARS coronavirus 2 (SARS-CoV-2) infection (COVID-19) (PubMed=33389257).
CC   Omics: Deep proteome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: Metabolome analysis.
OX   NCBI_TaxID=6945; ! Ixodes scapularis
SX   Sex unspecified
AG   Embryo
CA   Spontaneously immortalized cell line
DT   Created: 10-04-15; Last updated: 23-09-21; Version: 10
RX   Patent=US5869335;
RA   Munderloh U.G., Kurtti T.J., Kocan K.M., Blouin E.F., Ewing S.A.;
RT   "Propagating bovine parasite by incubation of undifferentiated cells
RT   under low oxygen increased carbon dioxide, with organic buffers;
RT   efficient, large scale production; diagnosis/vaccine for rocky
RT   mountains spotted fever.";
RL   Patent number US5869335, 09-Feb-1999.
RX   PubMed=8812616; DOI=10.1006/jipa.1996.0050;
RA   Kurtti T.J., Munderloh U.G., Andreadis T.G., Magnarelli L.A.,
RA   Mather T.N.;
RT   "Tick cell culture isolation of an intracellular prokaryote from the
RT   tick Ixodes scapularis.";
RL   J. Invertebr. Pathol. 67:318-321(1996).
RX   PubMed=16922866; DOI=10.1111/j.1462-5822.2006.00727.x;
RA   Singu V., Peddireddi L., Sirigireddy K.R., Cheng C.-M.,
RA   Munderloh U.G., Ganta R.R.;
RT   "Unique macrophage and tick cell-specific protein expression from the
RT   p28/p30-outer membrane protein multigene locus in Ehrlichia
RT   chaffeensis and Ehrlichia canis.";
RL   Cell. Microbiol. 8:1475-1487(2006).
RX   PubMed=17662657; DOI=10.1016/;
RA   Bell-Sakyi L., Zweygarth E., Blouin E.F., Gould E.A., Jongejan F.;
RT   "Tick cell lines: tools for tick and tick-borne disease research.";
RL   Trends Parasitol. 23:450-457(2007).
RX   PubMed=19242658; DOI=10.1007/s10493-009-9255-1;
RA   Billeter S.A., Diniz P.P.V.P., Battisti J.M., Munderloh U.G.,
RA   Breitschwerdt E.B., Levy M.G.;
RT   "Infection and replication of Bartonella species within a tick cell
RT   line.";
RL   Exp. Appl. Acarol. 49:193-208(2009).
RX   PubMed=22743047; DOI=10.1016/j.ttbdis.2012.05.002;
RA   Alberdi M.P., Dalby M.J., Rodriguez-Andres J., Fazakerley J.K.,
RA   Kohl A., Bell-Sakyi L.;
RT   "Detection and identification of putative bacterial endosymbionts and
RT   endogenous viruses in tick cell lines.";
RL   Ticks Tick Borne Dis. 3:137-146(2012).
RX   PubMed=25894426; DOI=10.1007/s10493-015-9908-1;
RA   Oliver J.D., Chavez A.S.O., Felsheim R.F., Kurtti T.J., Munderloh U.G.;
RT   "An Ixodes scapularis cell line with a predominantly neuron-like
RT   phenotype.";
RL   Exp. Appl. Acarol. 66:427-442(2015).
RX   PubMed=26424601; DOI=10.1074/mcp.M115.051938;
RA   Villar M., Ayllon N., Alberdi M.P., Moreno A., Moreno M., Tobes R.,
RA   Mateos-Hernandez L., Weisheit S., Bell-Sakyi L., de la Fuente J.;
RT   "Integrated metabolomics, transcriptomics and proteomics identifies
RT   metabolic pathways affected by Anaplasma phagocytophilum infection in
RT   tick cells.";
RL   Mol. Cell. Proteomics 14:3154-3172(2015).
RX   PubMed=29886187; DOI=10.1016/j.ttbdis.2018.05.015;
RA   Bell-Sakyi L., Darby A., Baylis M., Makepeace B.L.;
RT   "The Tick Cell Biobank: a global resource for in vitro research on
RT   ticks, other arthropods and the pathogens they transmit.";
RL   Ticks Tick Borne Dis. 9:1364-1371(2018).
RX   PubMed=32158404; DOI=10.3389/fphys.2020.00152;
RA   Al-Rofaai A., Bell-Sakyi L.;
RT   "Tick cell lines in research on tick control.";
RL   Front. Physiol. 11:152.1-152.7(2020).
RX   PubMed=33389257; DOI=10.1007/s10096-020-04106-0;
RA   Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.;
RT   "Culture of SARS-CoV-2 in a panel of laboratory cell lines,
RT   permissivity, and differences in growth profile.";
RL   Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021).