ID   C6/36
AC   CVCL_Z230
SY   Clone C6/36; Aedes albopictus clone C6/36; ATC-15(C6/36); AAL-C6/36; C6-36; SAAR-C6/36
DR   BTO; BTO:0005452
DR   CLO; CLO_0001672
DR   CLO; CLO_0002506
DR   CLDB; cl799
DR   ATCC; CRL-1660
DR   BCRC; 60114
DR   BCRJ; 0343
DR   CCRID; 4201INC-CCTCC00125
DR   CCRID; 5301INS-KCB82002YJ
DR   CCTCC; GDC0125
DR   ECACC; 89051705
DR   IZSLER; BS CL 219
DR   JCRB; IFO50010
DR   KCB; KCB 82002YJ
DR   NCBI_Iran; C612
DR   PRIDE; PXD004727
DR   Wikidata; Q54808220
RX   CelloPub=CLPUB00466;
RX   PubMed=690610;
RX   PubMed=2563994;
RX   PubMed=2861916;
RX   PubMed=3392770;
RX   PubMed=3611315;
RX   PubMed=3951024;
RX   PubMed=6126429;
RX   PubMed=6137452;
RX   PubMed=19951376;
RX   PubMed=20976219;
RX   PubMed=28404849;
RX   PubMed=29329394;
RX   PubMed=29973702;
RX   PubMed=33389257;
WW   https://pt.wikipedia.org/wiki/C6/36
WW   https://www.vectorbase.org/organisms/aedes-albopictus/c636
CC   Group: Insect cell line.
CC   Virology: Used for detection, propagation and analysis of mosquito-borne viruses.
CC   Virology: Supports replication of Sindbis virus (PubMed=3392770; PubMed=3951024).
CC   Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: Genome sequenced.
OX   NCBI_TaxID=7160; ! Aedes albopictus (Asian tiger mosquito)
HI   CVCL_Z223 ! ATC-15
SX   Sex unspecified
AG   Neonate larva
CA   Spontaneously immortalized cell line
DT   Created: 10-04-15; Last updated: 29-06-23; Version: 21
//
RX   CelloPub=CLPUB00466;
RA   Herrera R.J.;
RT   "Cytological, cytogenetic and biochemical studies on several permanent
RT   insect cell lines.";
RL   Thesis PhD (1982), Fordham University, United States.
//
RX   PubMed=690610; DOI=10.1099/0022-1317-40-3-531;
RA   Igarashi A.;
RT   "Isolation of a Singh's Aedes albopictus cell clone sensitive to
RT   Dengue and Chikungunya viruses.";
RL   J. Gen. Virol. 40:531-544(1978).
//
RX   PubMed=2563994; DOI=10.1007/BF02626177;
RA   Kuno G., Oliver A.;
RT   "Maintaining mosquito cell lines at high temperatures: effects on the
RT   replication of flaviviruses.";
RL   In Vitro Cell. Dev. Biol. 25:193-196(1989).
//
RX   PubMed=2861916;
RA   Kuno G., Gubler D.J., Velez M., Oliver A.;
RT   "Comparative sensitivity of three mosquito cell lines for isolation of
RT   dengue viruses.";
RL   Bull. World Health Organ. 63:279-286(1985).
//
RX   PubMed=3392770; DOI=10.1128/JVI.62.8.2629-2635.1988;
RA   Condreay L.D., Adams R.H., Edwards J., Brown D.T.;
RT   "Effect of actinomycin D and cycloheximide on replication of Sindbis
RT   virus in Aedes albopictus (mosquito) cells.";
RL   J. Virol. 62:2629-2635(1988).
//
RX   PubMed=3611315; DOI=10.1128/jcm.25.7.1221-1224.1987;
RA   White L.A.;
RT   "Susceptibility of Aedes albopictus C6/36 cells to viral infection.";
RL   J. Clin. Microbiol. 25:1221-1224(1987).
//
RX   PubMed=3951024; DOI=10.1128/JVI.58.1.81-86.1986;
RA   Condreay L.D., Brown D.T.;
RT   "Exclusion of superinfecting homologous virus by Sindbis
RT   virus-infected Aedes albopictus (mosquito) cells.";
RL   J. Virol. 58:81-86(1986).
//
RX   PubMed=6126429; DOI=10.1007/BF02796333;
RA   Brown S.E., Knudson D.L.;
RT   "Characterization of invertebrate cell lines. IV. Isozyme analyses of
RT   dipteran and acarine cell lines.";
RL   In Vitro 18:347-350(1982).
//
RX   PubMed=6137452; DOI=10.1007/BF02628962;
RA   Kuno G.;
RT   "Cultivation of mosquito cell lines in serum-free media and their
RT   effects on dengue virus replication.";
RL   In Vitro 19:707-713(1983).
//
RX   PubMed=19951376; DOI=10.1111/j.1365-2672.2009.04621.x;
RA   Voronin D.A., Tran-Van V., Potier P., Mavingui P.;
RT   "Transinfection and growth discrepancy of Drosophila Wolbachia strain
RT   wMel in cell lines of the mosquito Aedes albopictus.";
RL   J. Appl. Microbiol. 108:2133-2141(2010).
//
RX   PubMed=20976219; DOI=10.1371/journal.pone.0013398;
RA   Frentiu F.D., Robinson J., Young P.R., McGraw E.A., O'Neill S.L.;
RT   "Wolbachia-mediated resistance to dengue virus infection and death at
RT   the cellular level.";
RL   PLoS ONE 5:E13398-E13398(2010).
//
RX   PubMed=28404849; DOI=10.1128/JVI.00554-17;
RA   Xin Q.-L., Deng C.-L., Chen X., Wang J., Wang S.-B., Wang W., Deng F.,
RA   Zhang B., Xiao G.-F., Zhang L.-K.;
RT   "Quantitative proteomic analysis of mosquito C6/36 cells reveals host
RT   proteins involved in Zika virus infection.";
RL   J. Virol. 91:e00554.17.1-e00554.17.17(2017).
//
RX   PubMed=29329394; DOI=10.1093/gigascience/gix135;
RA   Miller J.R., Koren S., Dilley K.A., Puri V., Brown D.M., Harkins D.M.,
RA   Thibaud-Nissen F., Rosen B., Chen X.-G., Tu Z.-J., Sharakhov I.V.,
RA   Sharakhova M.V., Sebra R.P., Stockwell T.B., Bergman N.H., Sutton G.G.,
RA   Phillippy A.M., Piermarini P.M., Shabman R.S.;
RT   "Analysis of the Aedes albopictus C6/36 genome provides insight into
RT   cell line utility for viral propagation.";
RL   GigaScience 7:gix135.1-gix135.13(2018).
//
RX   PubMed=29973702; DOI=10.1038/s41598-018-28357-2;
RA   Gaburro J., Duchemin J.-B., Paradkar P.N., Nahavandi S., Bhatti A.;
RT   "Electrophysiological evidence of RML12 mosquito cell line towards
RT   neuronal differentiation by 20-hydroxyecdysdone.";
RL   Sci. Rep. 8:10109-10109(2018).
//
RX   PubMed=33389257; DOI=10.1007/s10096-020-04106-0;
RA   Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.;
RT   "Culture of SARS-CoV-2 in a panel of laboratory cell lines,
RT   permissivity, and differences in growth profile.";
RL   Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021).
//