Cellosaurus cell line Caco-2/AQ (CVCL_Z585)

• Mutation; HGNC; 583; APC; Simple; p.Gln1367Ter (c.4099C>T); ClinVar=VCV000376060; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 2514; CTNNB1; Simple; p.Gly245Ala (c.734G>C); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; 6770; SMAD4; Simple; p.Asp351His (c.1051G>C); ClinVar=VCV000375998; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; 11998; TP53; Simple; p.Glu204Ter (c.610G>T); ClinVar=VCV000977783; Zygosity=Homozygous (from parent cell line).
  

PubMed=9486194; DOI=10.1152/ajpgi.1998.274.2.G389
Chirayath M.V., Gajdzik L., Hulla W., Graf J., Cross H.S., Peterlik M.
Vitamin D increases tight-junction conductance and paracellular Ca2+ transport in Caco-2 cell cultures.
Am. J. Physiol. 274:G389-G396(1998)

PubMed=14599474; DOI=10.1016/S0887-2333(03)00095-X
Ranaldi G., Consalvo R., Sambuy Y., Scarino M.L.
Permeability characteristics of parental and clonal human intestinal Caco-2 cell lines differentiated in serum-supplemented and serum-free media.
Toxicol. In Vitro 17:761-767(2003)

PubMed=15868485; DOI=10.1007/s10565-005-0085-6
Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., Zucco F.
The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics.
Cell Biol. Toxicol. 21:1-26(2005)

PubMed=18205904; DOI=10.1186/1471-2407-8-13
Brozek W., Bises G., Fabjani G., Cross H.S., Peterlik M.
Clone-specific expression, transcriptional regulation, and action of interleukin-6 in human colon carcinoma cells.
BMC Cancer 8:13.1-13.9(2008)

PubMed=22940288; DOI=10.1016/j.jsbmb.2012.08.003
Hobaus J., Fetahu I.S., Khorchide M., Manhardt T., Kallay E.
Epigenetic regulation of the 1,25-dihydroxyvitamin D3 24-hydroxylase (CYP24A1) in colon cancer cells.
J. Steroid Biochem. Mol. Biol. 136:296-299(2013)

PubMed=24176760; DOI=10.1016/j.jsbmb.2013.10.015
Fetahu I.S., Hummel D.M., Manhardt T., Aggarwal A., Baumgartner-Parzer S., Kallay E.
Regulation of the calcium-sensing receptor expression by 1,25-dihydroxyvitamin D3, interleukin-6, and tumor necrosis factor alpha in colon cancer cells.
J. Steroid Biochem. Mol. Biol. 144:228-231(2014)