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Cellosaurus HC-04 (CVCL_Z631)

[Text version]

Cell line name HC-04
Synonyms HC04; HCO4
Accession CVCL_Z631
Resource Identification Initiative To cite this cell line use: HC-04 (RRID:CVCL_Z631)
Comments Problematic cell line: Possibly contaminated. Indicated (PubMed=24532842) to have a near genetic identity with Hep-G2 cells. But they are functionally different from Hep-G2 cells since they support sporozoite invasion and liver stage exoerythrocytic development of Plasmodium falciparum and Plasmodium vivax. But STR profile from BEI Resources is identical to that of Hep-G2.
Omics: Deep proteome analysis.
Sequence variations NRAS p.Gln61Leu (c.182A>T) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0027 (Hep-G2)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
STR profile Source(s): BEI_resources

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81811,12
D7S82010
D13S3179,13
D16S53912
TH019
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Publications

Patent=US7015036
Prachumsri J., Yimamnuaychok N.
Human liver cell line.
Patent number US7015036, 21-Mar-2006

PubMed=16687667; DOI=10.4269/ajtmh.2006.74.708
Sattabongkot J., Yimamnuaychok N., Leelaudomlipi S., Rasameesoraj M., Jenwithisuk R., Coleman R.E., Udomsangpetch R., Cui L., Brewer T.G.
Establishment of a human hepatocyte line that supports in vitro development of the exo-erythrocytic stages of the malaria parasites Plasmodium falciparum and P. vivax.
Am. J. Trop. Med. Hyg. 74:708-715(2006)

PubMed=22990793; DOI=10.1007/978-1-62703-026-7_27
Sinnis P., De La Vega P., Coppi A., Krzych U., Mota M.M.
Quantification of sporozoite invasion, migration, and development by microscopy and flow cytometry.
Methods Mol. Biol. 923:385-400(2013)

PubMed=24532842; DOI=10.1074/mcp.M113.035584
Tao D., King J.G., Tweedell R.E., Jost P.J., Boddey J.A., Dinglasan R.R.
The acute transcriptomic and proteomic response of HC-04 hepatoma cells to hepatocyte growth factor and its implications for Plasmodium falciparum sporozoite invasion.
Mol. Cell. Proteomics 13:1153-1164(2014)

Cross-references
Cell line collections ATCC; PTA-3441 - Discontinued
BEI_Resources; MRA-975
Other Wikidata; Q54881462
Entry history
Entry creation10-Apr-2015
Last entry updated05-Jul-2019
Version number10