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Cellosaurus MCF-7/MDD2 (CVCL_Z704)

[Text version]

Cell line name MCF-7/MDD2
Synonyms MDD2
Accession CVCL_Z704
Resource Identification Initiative To cite this cell line use: MCF-7/MDD2 (RRID:CVCL_Z704)
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8700512
Bacus S.S., Yarden Y., Oren M., Chin D.M., Lyass L., Zelnick C.R., Kazarov A., Toyofuku W., Gray-Bablin J., Beerli R.R., Hynes N.E., Nikiforov M., Haffner R., Gudkov A., Keyomarsi K.
Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells.
Oncogene 12:2535-2547(1996)

PubMed=11802204; DOI=10.1002/ijc.1628
Galmarini C.M., Clarke M.L., Falette N., Puisieux A., Mackey J.R., Dumontet C.
Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.
Int. J. Cancer 97:439-445(2002)

Cross-references
Other Wikidata; Q54904375
Entry history
Entry creation10-Apr-2015
Last entry update02-Jul-2020
Version number7