Cell line name |
MCF-7/MDD2 |
Synonyms |
MDD2 |
Accession |
CVCL_Z704 |
Resource Identification Initiative |
To cite this cell line use: MCF-7/MDD2 (RRID:CVCL_Z704) |
Comments |
Population: Caucasian. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0031 (MCF-7) |
Sex of cell |
Female |
Age at sampling |
69Y |
Category |
Cancer cell line |
Publications | PubMed=8700512 Bacus S.S., Yarden Y., Oren M., Chin D.M., Lyass L., Zelnick C.R., Kazarov A., Toyofuku W., Gray-Bablin J., Beerli R.R., Hynes N.E., Nikiforov M., Haffner R., Gudkov A.V., Keyomarsi K. Neu differentiation factor (Heregulin) activates a p53-dependent pathway in cancer cells. Oncogene 12:2535-2547(1996) PubMed=11802204; DOI=10.1002/ijc.1628 Galmarini C.M., Clarke M.L., Falette N., Puisieux A., Mackey J.R., Dumontet C. Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine. Int. J. Cancer 97:439-445(2002) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_Z704
|
Encyclopedic resources |
Wikidata; Q54904375
|
Entry history |
Entry creation | 10-Apr-2015 |
Last entry update | 05-Oct-2023 |
Version number | 13 |
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