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Cellosaurus K562-GEM (CVCL_Z735)

[Text version]

Cell line name K562-GEM
Synonyms K562/Gem; K/gem
Accession CVCL_Z735
Resource Identification Initiative To cite this cell line use: K562-GEM (RRID:CVCL_Z735)
Comments Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Derived from sampling site: Pleural effusion.
Sequence variations BCR-ABL1 gene fusion (from parent cell line).
Homozygous for TP53 p.Gln136fs*13 (c.406_407insC) (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line

PubMed=10500836; DOI=10.1007/978-1-4615-4811-9_63
Dumontet C., Bauchu E.C., Fabianowska K., Lepoivre M., Wyczechowska D., Bodin F., Rolland M.O.
Common resistance mechanisms to nucleoside analogues in variants of the human erythroleukemic line K562.
Adv. Exp. Med. Biol. 457:571-577(1999)

PubMed=11802204; DOI=10.1002/ijc.1628
Galmarini C.M., Clarke M.L., Falette N., Puisieux A., Mackey J.R., Dumontet C.
Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.
Int. J. Cancer 97:439-445(2002)

Other Wikidata; Q54899384
Entry history
Entry creation10-Apr-2015
Last entry update12-Mar-2020
Version number9