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Cellosaurus K562-GEM (CVCL_Z735)

[Text version]
Cell line name K562-GEM
Synonyms K562/Gem; K/gem
Accession CVCL_Z735
Resource Identification Initiative To cite this cell line use: K562-GEM (RRID:CVCL_Z735)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:175901; Gemcitabine (Gemzar).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=10500836; DOI=10.1007/978-1-4615-4811-9_63
Dumontet C., Callet-Bauchu E., Fabianowska K., Lepoivre M., Wyczechowska D., Bodin F., Rolland M.-O.
Common resistance mechanisms to nucleoside analogues in variants of the human erythroleukemic line K562.
Adv. Exp. Med. Biol. 457:571-577(1999)

PubMed=11802204; DOI=10.1002/ijc.1628
Galmarini C.M., Clarke M.L., Falette N., Puisieux A., Mackey J.R., Dumontet C.
Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.
Int. J. Cancer 97:439-445(2002)

Cross-references
Encyclopedic resources Wikidata; Q54899384
Entry history
Entry creation10-Apr-2015
Last entry update29-Jun-2023
Version number15