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Cellosaurus KY-ADR2 (CVCL_Z940)

[Text version]

Cell line name KY-ADR2
Accession CVCL_Z940
Resource Identification Initiative To cite this cell line use: KY-ADR2 (RRID:CVCL_Z940)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from sampling site: Brain; meninges.
Sequence variations Mutation; HGNC; 7989; NRAS; Simple; p.Gln61His (c.183A>C); ClinVar=VCV000375871; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Acute myelomonocytic leukemia (NCIt: C7463)
Acute myelomonocytic leukemia (ORDO: Orphanet_517)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1346 (KY821)
Sex of cell Male
Age at sampling 28Y
Category Cancer cell line

PubMed=7934146; DOI=10.1016/0145-2126(94)90071-X
Fukuda T., Kakihara T., Kamishima T., Ohnishi Y., Naito M., Kishi K., Shibata A., Tsuruo T.
Characterization of newly established adriamycin resistant human leukemic cell lines (KY-ADR1 and KY-ADR2).
Leuk. Res. 18:709-715(1994)

PubMed=12716468; DOI=10.1111/j.1349-7006.2002.tb01336.x
Shimizu H., Fukuda T., Ghazizadeh M., Nagashima M., Kawanami O., Suzuki T.
Molecular cytogenetic characterization of drug-resistant leukemia cell lines by comparative genomic hybridization and fluorescence in situ hybridization.
Jpn. J. Cancer Res. 93:902-910(2002)

Other Wikidata; Q54900769
Entry history
Entry creation10-Apr-2015
Last entry update20-May-2021
Version number9