ID   U2OS-LacO-I-SceI-TetO
AC   CVCL_ZC51
DR   Kerafast; ENH105-FP
RX   PubMed=25464843;
CC   Characteristics: Cell line designed to probe the role of chromatin condensation in DNA damage response (DDR) using a lac-repressor/operator-tethering system (Kerafast).
CC   Characteristics: Contains 2 integrated copies of a construct that consist of a I-Scel endonuclease cut site (I-SceIcs) sandwiched between 256 copies of the lac operator (lacO) and 96 copies of the tet operator (tetO) (Kerafast).
CC   Derived from sampling site: Bone; tibia.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0042 ! U2OS
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 02-07-20; Version: 1
//
RX   PubMed=25464843; DOI=10.1016/j.celrep.2014.10.060;
RA   Burgess R.C., Burman B., Kruhlak M.J., Misteli T.;
RT   "Activation of DNA damage response signaling by condensed chromatin.";
RL   Cell Rep. 9:1703-1717(2014).
//