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Cellosaurus CWR-R1-AD1 (CVCL_ZC60)

[Text version]

Cell line name CWR-R1-AD1
Synonyms R1-AD1
Accession CVCL_ZC60
Resource Identification Initiative To cite this cell line use: CWR-R1-AD1 (RRID:CVCL_ZC60)
Comments Characteristics: Clone of CWR-R1 that harbors one intact AR gene copy, express full-length AR and exhibit growth stimulation in response to androgens and growth suppression in response to AR antagonists, including enzalutamide (PubMed=24101480).
Derived from sampling site: Prostate.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4833 (CWR-R1)
Children:
CVCL_ZC61 (CWR-R1-D567 )CVCL_ZC62 (CWR-R1-I567 )
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=23117885; DOI=10.1158/0008-5472.CAN-12-3630
Li Y., Chan S.-C., Brand L.J., Hwang T.H., Silverstein K.A.T., Dehm S.M.
Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines.
Cancer Res. 73:483-489(2013)

PubMed=24101480; DOI=10.1073/pnas.1308587110
Nyquist M.D., Li Y., Hwang T.H., Manlove L.S., Vessella R.L., Silverstein K.A.T., Voytas D.F., Dehm S.M.
TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer.
Proc. Natl. Acad. Sci. U.S.A. 110:17492-17497(2013)

Cross-references
Cell line collections Kerafast; EMN024-FP
Encyclopedic resources Wikidata; Q98125805
Entry history
Entry creation02-Jul-2020
Last entry update20-May-2021
Version number4