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Cellosaurus CWR-R1-I567 (CVCL_ZC62)

[Text version]
Cell line name CWR-R1-I567
Synonyms R1-I567
Accession CVCL_ZC62
Resource Identification Initiative To cite this cell line use: CWR-R1-I567 (RRID:CVCL_ZC62)
Comments Population: Caucasian.
Characteristics: Using TALEN AR introns 4-7 were inverted. This cell line exclusively expresses the ARv567es isoform that skips exons 5 to 7 (PubMed=24101480).
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_ZC60 (CWR-R1-AD1)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=24101480; DOI=10.1073/pnas.1308587110
Nyquist M.D., Li Y.-M., Hwang T.H., Manlove L.S., Vessella R.L., Silverstein K.A.T., Voytas D.F., Dehm S.M.
TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer.
Proc. Natl. Acad. Sci. U.S.A. 110:17492-17497(2013)

Cross-references
Cell line collections (Providers) Kerafast; EMN029-FP
Cell line databases/resources cancercelllines; CVCL_ZC62
Encyclopedic resources Wikidata; Q98125807
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number7