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Cellosaurus LNCaP-95 (CVCL_ZC87)

[Text version]

Cell line name LNCaP-95
Synonyms LNCaP 95; LNCaP95; LN95
Accession CVCL_ZC87
Resource Identification Initiative To cite this cell line use: LNCaP-95 (RRID:CVCL_ZC87)
Comments Population: Caucasian.
Characteristics: Androgen-independent.
Doubling time: 52.2 hours (PubMed=32954481).
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (PubMed=28928128).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Children:
CVCL_A4DX (LNCaP95 clone 2-C6 )CVCL_A4DY (LNCaP95 clone 2-D3 )CVCL_A4DZ (LNCaP95 clone A7 )
CVCL_A4EA (LNCaP95 clone D2 )CVCL_A4EB (LNCaP95 clone D3 )CVCL_A4EC (LNCaP95 clone E2 )
CVCL_A4ED (LNCaP95 clone F2 )
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=10420156; DOI=10.1002/(SICI)1097-0045(19990901)40:4<269::AID-PROS9>3.0.CO;2-6
Pflug B.R., Reiter R.E., Nelson J.B.
Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines.
Prostate 40:269-273(1999)

PubMed=28928128; DOI=10.1158/0008-5472.CAN-17-0320
Van Etten J.L., Nyquist M., Li Y., Yang R., Ho Y., Johnson R., Ondigi O., Voytas D.F., Henzler C., Dehm S.M.
Targeting a single alternative polyadenylation site coordinately blocks expression of androgen receptor mRNA splice variants in prostate cancer.
Cancer Res. 77:5228-5235(2017)

PubMed=32954481; DOI=10.1007/s13577-020-00435-6
Leung J.K., Tam T., Wang J., Sadar M.D.
Isolation and characterization of castration-resistant prostate cancer LNCaP95 clones.
Hum. Cell 34:211-218(2021)

Cross-references
Anatomy/cell type resources BTO; BTO:0006264
Encyclopedic resources Wikidata; Q98126929
Entry history
Entry creation02-Jul-2020
Last entry update23-Jun-2022
Version number5