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Cellosaurus A388.6TG.c2 (CVCL_ZF53)

[Text version]
Cell line name A388.6TG.c2
Synonyms A3886TGc2
Accession CVCL_ZF53
Resource Identification Initiative To cite this cell line use: A388.6TG.c2 (RRID:CVCL_ZF53)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: ChEBI; CHEBI:21759; N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Arg832Cys (c.2494C>T); ClinVar=VCV000936373; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Heterozygous (from parent cell line).
Disease Skin squamous cell carcinoma (NCIt: C4819)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1063 (A-388)
Children:
CVCL_ZF54 (A388.6TG.c2.neoc1)
Sex of cell Male
Age at sampling 86Y
Category Cancer cell line
Publications

PubMed=1358434
Conway K., Morgan D., Phillips K.K., Yuspa S.H., Weissman B.E.
Tumorigenic suppression of a human cutaneous squamous cell carcinoma cell line in the nude mouse skin graft assay.
Cancer Res. 52:6487-6495(1992)

PubMed=10942591; DOI=10.1006/excr.2000.4946
Merrihew R.V., Cruickshank R.D., Conway K., Weissman B.E.
Altered response of a human squamous cell carcinoma cell line to 1, 25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11.
Exp. Cell Res. 259:191-203(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZF53
Encyclopedic resources Wikidata; Q98125444
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number6